the leading objection to such a picture is, why then the experiments can notice Zn1-Zn2 interacting with a wide-open up SSB, and a mostly bent DNA hairpin?
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The resulting values are approximated, even so they can provide a qualitative appraisal with the binding energies linked to the protein-DNA interaction.
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Though these structural scientific studies served in knowledge numerous specifics with the binding of PARP-one to broken DNA and its consequent conformational alterations, there is no distinct-cut response within the system by which the change in conformation of DNA occurs.
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